Effect of a Reduced-Calorie Diet on Plasma Levels of Inflammatory and Metabolic Factors in Overweight/Obese Patients with Cardiovascular Risk Factors

Background: Calorie restriction without malnutrition is likely to improve cardiovascular risk factors. Objectives: The aim of this study was investigate calorie on markers cardiometabolic in overweight/obese adults with Methods: In a parallel controlled trial, patients overweight or obesity and one more factor were randomized modest reduced-calorie diet (75% the total calculated energy requirements) control (no restriction) groups followed up for two months. Body weight, dietary intake, fasting plasma levels C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell (VCAM-1), brain-derived neurotrophic (BDNF), neuropeptide Y (NPY), lipids, glycemic factors measured at baseline, after differences analyzed analysis covariance (ANCOVA). Results: Sixty-six participants (33 each group) completed study. weight changed group (- 3.05 ± 2.65 kg), blood pressure improved (systolic -6.96 12.04 diastolic - 3.90 8.97 mmHg). ICAM-1 (change from baseline 0.45 1.99 ng/mL, P = 0.033, ANCOVA), MCP-1 0.50 pg/mL, 0.011, low-density lipoprotein cholesterol 9.35 19.61 mg/dL, < 0.001, triglyceride -33.66 49.08, but BDNF, NPY, other not different. Conclusions: subjects which have been under medical treatment risk-reducing medications, loss induced by lipid profile, pressure, reduced had no effect BDNF